Article
Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline.
Alzheimer's research & therapy - 3 Jan 2022
González-Domínguez Raúl, Castellano-Escuder Pol, Lefèvre-Arbogast Sophie, Low Dorrain Y, Du Preez Andrea, Ruigrok Silvie R, Lee Hyunah, Helmer Catherine, Pallàs Mercè, Urpi-Sarda Mireia, Sánchez-Pla Alex, Korosi Aniko, Lucassen Paul J, Aigner Ludwig, Manach Claudine, Thuret Sandrine, Samieri Cécilia, Andres-Lacueva Cristina
Abstract excerpt
BACKGROUND: Fatty acids play prominent roles in brain function as they participate in structural, metabolic and signaling processes. The homeostasis of fatty acids and related pathways is known to be impaired in cognitive decline and dementia, but the relationship between these metabolic disturbances and common risk factors, namely the ɛ4 allele of the apolipoprotein E (ApoE-ɛ4) gene and sex, remains elusive....
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