Article

A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer’s Disease

2025-04-28

Abstract excerpt

<h4>SUMMARY</h4> The etiology of Alzheimer’s Disease (AD) remains largely unclear but is likely driven by gene-environment interactions. Here, we present a multi-organ untargeted metabolomics dataset (2,271 samples) generated from five tissue types in two genetic AD mouse models under colonized or germ-free conditions, complemented by shotgun metagenomics sequencing data (666 samples). Systems-level analyses of 3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e8e6967-a9cb-5114-ad46-432d9ec171e3
DOI: 10.1101/2025.04.28.651123

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Multi-Organ Murine Metabolomics Atlas Reveals Molecular Dysregulations in Alzheimer’s DiseaseDOI 10.1101/2025.04.28.651123Read

Towards understanding brain-gut-microbiome connections in Alzheimer’s diseaseSemantic proximity Read

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer’s diseaseSemantic proximity Read

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s diseaseSemantic proximity Read

Metabolomics profiling reveals distinct, sex‐specific signatures in serum and brain metabolomes in mouse models of Alzheimer's diseaseSemantic proximity Read

Brain cross-omics integration in Alzheimer’s diseaseSemantic proximity Read

Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

A seven-year longitudinal study of the Alzheimer’s disease blood metabolomeSemantic proximity Read

Sex-Specific Gut Microbiome Functions in Alzheimer’s Disease BXD MiceSemantic proximity Read

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brainSemantic proximity Read

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriersSemantic proximity Read

Pathway-based integration of multi-omics data reveals lipidomics alterations validated in an Alzheimer’s Disease mouse model and risk loci carriersSemantic proximity Read

APOE Genotype Influences on The Brain Metabolome of Aging Mice – Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 GenotypeSemantic proximity Read