Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-10-deficient mice develop chronic enterocolitis.

Cell - 22 Oct 1993

Kühn R, Löhler J, Rennick D, Rajewsky K, Müller W

Abstract excerpt

Interleukin-10 (IL-10) affects the growth and differentiation of many hemopoietic cells in vitro; in particular, it is a potent suppressor of macrophage and T cell functions. In IL-10-deficient mice, generated by gene targeting, lymphocyte development and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis. Alterations in intestine include extensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Body Weight
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Mice, Mutant Strains

Share to Mutagenesis, Insertional

Share to Mutation

Source

Identifiers

PMID: 8402911
DOI: 10.1016/0092-8674(93)80068-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-10-deficient mice develop chronic enterocolitis.PMID 8402911Read ↗

Chronic Colitis in IL-10<sup>-/-</sup>Mice: Insufficient Counter Regulation of a Th1 ResponseSemantic proximity Read ↗

Loss of IL-10 signaling promotes IL-22 dependent host defenses against acute <i>Clostridioides difficile</i> infectionSemantic proximity Read ↗

A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse.Semantic proximity Read ↗

Interleukin-10 gene knock-out mice: a model of chronic inflammation.Semantic proximity Read ↗

Giardia Infection of the Small Intestine Induces Chronic Colitis in Genetically Susceptible Hosts.Semantic proximity Read ↗

Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.Semantic proximity Read ↗

Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birdsSemantic proximity Read ↗

Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model.Semantic proximity Read ↗

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside.Semantic proximity Read ↗

Disruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) mice.Semantic proximity Read ↗

IL-10 and IL-10 receptor defects in humans.Semantic proximity Read ↗

Changes in composition of caecal microbiota associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.