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Article

Chronic Colitis in IL-10<sup>-/-</sup>Mice: Insufficient Counter Regulation of a Th1 Response

1 Jan 2000

Abstract excerpt

IL-10-deficient (IL-10-/-) mice, generated by a gene-targeted mutation, develop abnormal immune responses as a result of uncontrolled interactions between antigen presenting cells and lymphocytes. The studies reviewed herein have focused on the enterocolitis that spontaneously develops in IL-10-/- mice. Not unexpectedly, heightened production of proinflammatory mediators accompanied pathologic changes in the...

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PMID: 10723680
DOI: 10.3109/08830180009048392

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