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Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to <i>Clostridioides difficile</i> colonization and infection

2020-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Clostridioides difficile has emerged as a noteworthy pathogen in patients with inflammatory bowel disease (IBD). Concurrent IBD and CDI is associated with increased morbidity and mortality compared to CDI alone. IBD is associated with alterations of the gut microbiota, an important mediator of colonization resistance to C. difficile . Here, we describe and utilize a mouse model to explore the r...

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Identifiers and source

Literature Corpus work
03644440-20d0-59da-9b72-8722fd3315b3
DOI
10.1101/2020.07.30.230094
Open publication

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