Article

Disease tolerant mice shelter a pathogenic intestinal microbiota able to trigger lethal disease in low tolerant hosts

2025-02-26

Abstract excerpt

Disease tolerance is a defensive strategy that limits tissue damage during infection. Macrophage migration inhibitory factor (MIF)-deficient mice ( Mif -/- ) are protected in different models of infection and intestinal inflammation due to unclear disease tolerance mechanisms, whereas low disease-tolerant Il10 -/- mice develop microbiota-dependent spontaneous gut inflammation. Here, we examined whether IL-10 i...

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Literature Corpus work: 2b87b5d1-9347-5b74-9acf-3675fc5d9d7e
DOI: 10.1101/2025.02.20.639353

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