Article

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

2023-12-15

Abstract excerpt

Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2α P ) terminates signalling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a PP1 catalytic subunit, the conserved C-terminally located ∼70 amino acid core of a substrate-specific regulatory subunit (PPP1R15A/GADD34 or PPP1R15B/CReP) and G-actin (an essential co-factor) efficiently depho...

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Literature Corpus work: 1ded531b-4483-573d-a3f7-aab38fc9ca28
DOI: 10.1101/2023.12.15.571226

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