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Article

Sugar phosphate activation of the stress sensor eIF2B.

Nature communications - 8 Jun 2021

Hao Qi, Heo Jin-Mi, Nocek Boguslaw P, Hicks Kevin G, Stoll Vincent S, Remarcik Clint, Hackett Sean, LeBon Lauren, Jain Rinku, Eaton Dan, Rutter Jared, Wong Yao Liang, Sidrauski Carmela

Abstract excerpt

The multi-subunit translation initiation factor eIF2B is a control node for protein synthesis. eIF2B activity is canonically modulated through stress-responsive phosphorylation of its substrate eIF2. The eIF2B regulatory subcomplex is evolutionarily related to sugar-metabolizing enzymes, but the biological relevance of this relationship was unknown. To identify natural ligands that might regulate eIF2B, we...

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Identifiers

PMID: 34103529
DOI: 10.1038/s41467-021-23836-z
PMCID: PMC8187479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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