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Article

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.

eLife - 16 Mar 2015

Chen Ruming, Rato Cláudia, Yan Yahui, Crespillo-Casado Ana, Clarke Hanna J, Harding Heather P, Marciniak Stefan J, Read Randy J, Ron David

Abstract excerpt

Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis at the waning of stress responses and requires a PP1 catalytic subunit and a regulatory subunit, PPP1R15A/GADD34 or PPP1R15B/CReP. Surprisingly, PPP1R15-PP1 binary complexes reconstituted in vitro lacked substrate selectivity. However, selectivity was restored by crude cell lysate or purified G-actin, which joined...

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Identifiers

PMID: 25774600
DOI: 10.7554/eLife.04871
PMCID: PMC4394352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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