Article

Choice of PP1 catalytic subunit affects neither requirement for G-actin nor insensitivity to Sephin1 of PPP1R15A-regulated eIF2αP dephosphorylation

2017-12-04

Abstract excerpt

<h4>ABSTRACT</h4> The integrated stress response (ISR) is regulated by kinases that phosphorylate the α subunit of translation initiation factor 2 and phosphatases that dephosphorylate it. Genetic and biochemical observations indicate that the eIF2α P -directed holophosphatase - a therapeutic target in diseases of protein misfolding - is comprised of a regulatory, PPP1R15, and a catalytic, Protein Phosphatase 1...

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Literature Corpus work: 590c8cdc-511a-5805-bbd3-1925e2c14deb
DOI: 10.1101/228809

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