Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model

Abstract excerpt

Significance Statement Extreme stress, such as life-threatening sepsis, triggers the integrated stress response and causes translation shutdown, a hallmark of late-phase, sepsis-induced kidney injury. Although a brief period of translation shutdown could be cytoprotective, prolonged translation repression can have negative consequences and has been shown to contribute to sepsis-induced kidney failure. Using a...

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