Article

Substrate recognition determinants of human eIF2α phosphatases

2021-07-12

Abstract excerpt

Phosphorylation of the translation initiation factor eIF2α is a rapid and vital cellular defence against many forms of stress. In mammals, the levels of eIF2α phosphorylation are set through the antagonistic action of four protein kinases and two heterodimeric protein phosphatases. The phosphatases are composed of the catalytic subunit PP1 and one of two related non-catalytic subunits, PPP1R15A or PPP1R15B (R15A o...

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Literature Corpus work: 6c465529-496a-521b-9b32-e2a3cb671b0d
DOI: 10.1101/2021.07.12.452048

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