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Article

Substrate recognition determinants of human eIF2α phosphatases.

Open biology - 1 Dec 2021

Hodgson George, Andreeva Antonina, Bertolotti Anne

Abstract excerpt

Phosphorylation of the translation initiation factor eIF2α is a rapid and vital cellular defence against many forms of stress. In mammals, the levels of eIF2α phosphorylation are set through the antagonistic action of four protein kinases and two heterodimeric protein phosphatases. The phosphatases are composed of the catalytic subunit PP1 and one of two related non-catalytic subunits, PPP1R15A or PPP1R15B (R15A...

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PMID: 34847777
DOI: 10.1098/rsob.210205
PMCID: PMC8633803

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