Article

Increased gene dosage and mRNA expression from chromosomal duplications in <i>C. elegans</i>

2022-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Isolation of copy number variations and chromosomal duplications at high frequency in the laboratory suggested that Caenorhabditis elegans tolerates increased gene dosage. Here we addressed if a general dosage compensation mechanism acts at the level of mRNA expression in C. elegans . We characterized gene dosage and mRNA expression in three chromosomal duplications and a fosmid integration st...

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Literature Corpus work: d6b14309-0798-5354-b63f-8e6f373a5938
DOI: 10.1101/2022.03.22.485368

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