Article

Time and space dimensions of gene dosage imbalance of aneuploidies revealed by single cell transcriptomes

2018-09-23

Abstract excerpt

The mechanisms underlying cellular and organismal phenotypes due to copy number alterations (CNA) are not fully understood. Aneuploidy is a major source of gene dosage imbalance due to CNA and viable human trisomies are model disorders of altered gene expression. To understand the cellular impact of gene dosage imbalance, we studied gene and allele specific expression (ASE) of 9668 single-cell fibroblasts in triso...

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Literature Corpus work: 446718bb-c5b6-5240-b5b1-bdea5c21d60a
DOI: 10.1101/424887

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