Article

Fast and parallel nanoscale 3D tracking of heterogeneous mammalian chromatin dynamics

2021-10-24

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin organization and dynamics are critical for gene regulation. In this work we present a methodology for fast and parallel 3D tracking of multiple chromosomal loci of choice over many thousands of frames on various time scales. We achieved this by developing and combining fluorogenic and replenishable nanobody arrays, engineered point spread functions, and light sheet illumination. The re...

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Literature Corpus work: 1de84618-5c45-5fc6-9538-6db1eb4afe23
DOI: 10.1101/2021.10.24.465625

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