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Article

Quantitative investigation of the effects of DNA modifications and protein mutations on MeCP2-MBD-DNA interactions.

International journal of biological macromolecules - 30 Aug 2023

Wang Qihang, Luo Song, Xiong Danyang, Xu Xiaole, Zhao Xiaoyu, Duan Lili

Abstract excerpt

DNA methylation as an important epigenetic marker, has gained attention for the significance of three oxidative modifications (hydroxymethyl-C (hmC), formyl-C (fC), and carboxyl-C (caC)). Mutations occurring in the methyl-CpG-binding domain (MBD) of MeCP2 result in Rett. However, uncertainties persist regarding DNA modification and MBD mutation-induced interaction changes. Here, molecular dynamics simulations...

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PMID: 37423448
DOI: 10.1016/j.ijbiomac.2023.125690

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