LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein that is involved in transcriptional regulation and chromatin remodeling. MeCP2 exists in two isoforms, MeCP2 E1 and MeCP2 E2, which share the same functional domains. Loss-of-function mutations in the MeCP2 gene are the main cause of Rett syndrome (RTT). Previous studies identified a direct interaction between MeCP2 and Lens Epitheliu...

Topics

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• Binding Sites
• HEK293 Cells
• Intercellular Signaling Peptides and Proteins
• Methyl-CpG-Binding Protein 2
• NIH 3T3 Cells
• Protein Interaction Domains and Motifs
• Protein Multimerization
• Rett Syndrome

Identifiers and source

Literature Corpus work

030efdb5-c309-5846-9719-c11a7dee9690

DOI

10.1101/2024.04.24.590897