Methyl-CpG Binding Protein 2 Reads Histone Methylation via an Aromatic Cage to Regulate Gene Expression and Chromatin Association

Abstract excerpt

Methyl-CpG binding protein 2 (MeCP2) is a DNA methylation reader, which is highly expressed in the central nervous system. Loss of function mutation of MeCP2, which impairs DNA binding, causes Rett syndrome, while gain of MeCP2 function causes MeCP2 duplication syndrome. MeCP2 functions as both transcription activator and repressor but its full range of activity remains largely unknown. Recent study suggests that...

Topics

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• Binding Sites
• DNA
• Methyl-CpG-Binding Protein 2
• Molecular Docking Simulation
• Molecular Dynamics Simulation
• Protein Binding
• Protein Conformation
• Rotation

Identifiers and source

Literature Corpus work

f258cc4b-7ec5-5a71-9721-71a36457aad6

DOI

10.1101/2025.05.10.653294