Article

MeCP2 NID interaction with RNA: Implications for Rett Syndrome-Relevant Protein Regulation

2025-11-19

Abstract excerpt

Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Rett syndrome. Pathogenic missense mutation hotspots exist in the protein’s Methyl DNA binding Domain (MBD), and the NCoR Interaction Domain (NID), indicating these regions as critical for MeCP2 function. The NID binds to a co-repressor complex allowing transcriptional repression at target genes. A putative RNA Binding Domain (RBD) was...

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Literature Corpus work: ec939579-7f25-573a-ae54-72ad40a1735e
DOI: 10.1101/2025.11.19.689340

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