Article
MeCP2 NID interaction with RNA: implications for Rett syndrome-relevant protein regulation.
Human molecular genetics - 15 Apr 2026
Good Katrina V, Strickfaden Hilmar, Muhammad Tahir, Vincent John B, Hendzel Michael, Nelson Christopher J, Ausió Juan
Abstract excerpt
Mutations in the X-linked MECP2 gene cause the progressive neurodevelopmental disorder Rett syndrome. Pathogenic missense mutation hotspots exist in the protein's Methyl DNA binding Domain (MBD), and the Nuclear receptor Co-Repressor (NCoR) Interaction Domain (NID), indicating these regions as critical for MeCP2 function. The NID binds to a co-repressor complex allowing transcriptional repression at target genes....
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