Article
Comprehensive analysis of tumour initiation, spatial and temporal progression under multiple lines of treatment
2018-12-31
Abstract excerpt
Driver mutations alter cells from normal to cancer through several evolutionary epochs: premalignancy, early malignancy, subclonal diversification, metastasis and resistance to therapy. Later stages of disease can be explored through analyzing multiple samples collected longitudinally, on or between successive treatments, and finally at time of autopsy. It is also possible to study earlier stages of cancer develop...
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Identifiers and source
- Literature Corpus work
- 1da745ff-eeec-5db1-b48e-0a42967279a7
- DOI
- 10.1101/508127