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Article

USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in mice.

Brain, behavior, and immunity - 1 Aug 2020

Zhao JiaYi, Bi Wei, Zhang JiaWei, Xiao Shu, Zhou RuiYi, Tsang Chi Kwan, Lu DaXiang, Zhu Lihong

Abstract excerpt

Ubiquitin-specific protease 8 (USP8) regulates inflammation in vitro; however, the mechanisms by which USP8 inhibits neuroinflammation and its pathophysiological functions are not completely understood. In this study, we aimed to determine whether USP8 exerts neuroprotective effects in a mouse model of lipopolysaccharide (LPS)-induced cognitive and motor impairment. We commenced intracerebroventricular USP8...

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PMID: 32335193
DOI: 10.1016/j.bbi.2020.04.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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