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Growth Inhibition and Apoptosis Due to Restoration of E2A Activity in T Cell Acute Lymphoblastic Leukemia Cells

1 Feb 1999

Abstract excerpt

Two models have been proposed for the molecular mechanism by which the Tal1 oncogene causes T cell acute lymphoblastic leukemia (T-ALL). The activation model suggests that Tal1 as heterodimers with the E2A transcription factor activates the expression of oncogenes. The inhibition model postulates that Tal1 interferes with the tumor-suppressing function of E2A. In the Jurkat T cell line, originally derived from a...

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PMID: 9927512
DOI: 10.1084/jem.189.3.501

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Growth Inhibition and Apoptosis Due to Restoration of E2A Activity in T Cell Acute Lymphoblastic Leukemia CellsPMID 9927512Read ↗

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Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

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