Article

Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic Leukemia

2021-11-08

Abstract excerpt

T lymphocyte acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease affecting T cells at multiple stages of their development and is characterized by frequent genomic alterations. The transcription factor LEF1 is inactivated through mutation in a subset of T-ALL cases but elevated LEF1 expression and activating mutations have also been identified in this disease. Here we show, in a murine model of T-ALL,...

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Literature Corpus work: 8e1ae3d6-28f9-5e33-8b2f-d3d36657e819
DOI: 10.1101/2021.11.08.467708

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Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic LeukemiaDOI 10.1101/2021.11.08.467708Read

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