Article
APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains.
Molecular brain - 8 Jul 2021
Ojo Joseph O, Reed Jon M, Crynen Gogce, Vallabhaneni Prashanthi, Evans James, Shackleton Benjamin, Eisenbaum Maximillian, Ringland Charis, Edsell Anastasia, Mullan Michael, Crawford Fiona, Bachmeier Corbin
Abstract excerpt
Cerebrovascular dysfunction is a hallmark feature of Alzheimer's disease (AD). One of the greatest risk factors for AD is the apolipoprotein E4 (E4) allele. The APOE4 genotype has been shown to negatively impact vascular amyloid clearance, however, its direct influence on the molecular integrity of the cerebrovasculature compared to other APOE variants (APOE2 and APOE3) has been largely unexplored. To address...
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