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Article

APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia.

Annals of clinical and translational neurology - 1 Feb 2025

Philippi Sarah M, Bp Kailash, Raj Towfique, Castellano Joseph M

Abstract excerpt

OBJECTIVE: Recent work has bolstered the possibility that peripheral changes may be relevant to Alzheimer's disease pathogenesis in the brain. While age-associated blood-borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. Here, we investigate whether APOE allelic variation or presence of...

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Identifiers

PMID: 39689057
DOI: 10.1002/acn3.52250
PMCID: PMC11822792

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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