Article
Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.
Cell - 19 Apr 2018
Mitchell Thomas J, Turajlic Samra, Rowan Andrew, Nicol David, Farmery James H R, O'Brien Tim, Martincorena Inigo, Tarpey Patrick, Angelopoulos Nicos, Yates Lucy R, Butler Adam P, Raine Keiran, Stewart Grant D, Challacombe Ben, Fernando Archana, Lopez Jose I, Hazell Steve, Chandra Ashish, Chowdhury Simon, Rudman Sarah, Soultati Aspasia, Stamp Gordon, Fotiadis Nicos, Pickering Lisa, Au Lewis, Spain Lavinia, Lynch Joanna, Stares Mark, Teague Jon, Maura Francesco, Wedge David C, Horswell Stuart, Chambers Tim, Litchfield Kevin, Xu Hang, Stewart Aengus, Elaidi Reza, Oudard Stéphane, McGranahan Nicholas, Csabai Istvan, Gore Martin, Futreal P Andrew, Larkin James, Lynch Andy G, Szallasi Zoltan, Swanton Charles, Campbell Peter J
Abstract excerpt
Clear cell renal cell carcinoma (ccRCC) is characterized by near-universal loss of the short arm of chromosome 3, deleting several tumor suppressor genes. We analyzed whole genomes from 95 biopsies across 33 patients with clear cell renal cell carcinoma. We find hotspots of point mutations in the 5' UTR of TERT, targeting a MYC-MAX-MAD1 repressor associated with telomere lengthening. The most common structural...
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