Article

Somatic mutant selection is altered by prior NOTCH1 mutation in aging esophageal epithelium

2024-09-29

Abstract excerpt

The ageing mid esophagus is progressively colonized by somatic mutations, including oncogenic TP53 and antioncogenic NOTCH1 mutants. Most esophageal squamous carcinomas are TP53 mutant, NOTCH1 wild type. By middle age, much of the esophagus is NOTCH1 mutant. We hypothesised that prior NOTCH1 mutation may alter subsequent mutant selection. Here we show that selection of mutant NOTCH2 was increased and mutant TP53 d...

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Literature Corpus work: 1d40140f-0b7f-5830-a468-6d7f7c573f94
DOI: 10.1101/2024.09.26.615123

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