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Article

NOTCH1 Mutations Inhibit Tumor Growth in the Esophageal Epithelium.

Cancer discovery - 1 Mar 2023

Abstract excerpt

NOTCH1 mutations have opposing effects on cell fitness in normal and cancerous esophageal epithelia.

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 36705479
DOI: 10.1158/2159-8290.CD-RW2023-014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH1 Mutations Inhibit Tumor Growth in the Esophageal Epithelium.PMID 36705479Read ↗

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth.Semantic proximity Read ↗

<i>Notch1</i> mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growthSemantic proximity Read ↗

Early <i>NOTCH1</i> mutation is positively selected but epistatically suppresses evolution of later esophageal squamous-cell carcinoma driversSemantic proximity Read ↗

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium.Semantic proximity Read ↗

Somatic mutant selection is altered by prior NOTCH1 mutation in aging esophageal epitheliumSemantic proximity Read ↗

NOTCH mutations: multiple faces in human malignancies.Semantic proximity Read ↗

Cell competition: winning out by losing notch.Semantic proximity Read ↗

The multifaceted role of Notch in cancer.Semantic proximity Read ↗

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competitionSemantic proximity Read ↗

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.Semantic proximity Read ↗

Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia.Semantic proximity Read ↗

A mutation in NOTCH1 ligand binding region detected in patients with oral squamous cell carcinoma reduces NOTCH1 oncogenic effect.Semantic proximity Read ↗

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