Article

Branch point evolution controls species-specific alternative splicing and regulates long term potentiation

2022-09-11

Abstract excerpt

Regulation and functionality of species-specific alternative splicing has remained enigmatic to the present date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants and plays a key role in learning and memory. Here, we identify and characterize several primate-specific CAMK2B splice isoforms, which show altered kinetic properties and changes in substrate specificity....

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Literature Corpus work: 5ef190c7-848f-5d7f-9dc5-fe9c0ca30ca7
DOI: 10.1101/2022.09.09.507289

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