Article
Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
The Journal of biological chemistry - 15 Jun 2018
Posner Mareike G, Upadhyay Abhishek, Ishima Rieko, Kalli Antreas C, Harris Gemma, Kremerskothen Joachim, Sansom Mark S P, Crennell Susan J, Bagby Stefan
Abstract excerpt
Kidney- and brain-expressed protein (KIBRA), a multifunctional scaffold protein with around 20 known binding partners, is involved in memory and cognition, organ size control via the Hippo pathway, cell polarity, and membrane trafficking. KIBRA includes tandem N-terminal WW domains, a C2 domain, and motifs for binding atypical PKC and PDZ domains. A naturally occurring human KIBRA variant involving residue...
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