Article

Integrating comparative modeling and accelerated simulations reveals conformational and energetic basis of actomyosin force generation

2022-09-23

Abstract excerpt

Muscle contraction is performed by arrays of contractile proteins in the sarcomere. Serious heart diseases, such as cardiomyopathy, can often be results of mutations in myosin and actin. Direct characterization of how small changes in the myosin-actin complex impact its force production remains challenging. Molecular dynamics (MD) simulations, although capable of studying protein structurefunction relationships, a...

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Literature Corpus work: 8edb9aa6-66cd-53a2-bc3c-92582f1e1dd1
DOI: 10.1101/2022.09.22.508219

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