Article

Bacteria-macrophage interactions in the pathogenesis of Crohn's disease

2017-01-01

Abstract excerpt

Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by bacteria, particularly E. coli that replicate inside macrophage phagolysosomes. In this thesis several hypotheses were tested: (i) that CD macrophages might be defective at killing and or responding to Gram-negative bacteria, particularly E. coli; (ii) that killing of phagocytosed ba...

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Literature Corpus work: 1d2ade0a-eb55-5bd3-aa44-46d9cf7eb7a2
DOI: 10.17638/03008673

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