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Article

Defective macrophage handling of Escherichia coli in Crohn's disease.

Journal of gastroenterology and hepatology - 1 Aug 2015

Elliott T R, Hudspith B N, Rayment N B, Prescott N J, Petrovska L, Hermon-Taylor J, Brostoff J, Boussioutas A, Mathew C G, Sanderson J D

Abstract excerpt

BACKGROUND AND AIM: Escherichia coli can be isolated from lamina propria macrophages in Crohn's disease (CD), and their intramacrophage persistence may provide a stimulus for inflammation. To further determine the contributions of macrophage dysfunction and E. coli pathogenicity to this, we aimed to compare in vitro functioning of macrophages from patients with CD and healthy controls (HC) in response to...

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Source

Identifiers

PMID: 25809337
DOI: 10.1111/jgh.12955

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IRGM
NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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