Article

Hydroxychloroquine ameliorates DSS-induced colitis by inhibiting M1 macrophage polarization through NF-κB/NLRP3 signaling pathway

2022-10-11

Abstract excerpt

<h4>Background and Aims: </h4> Polarization of macrophages to the M1 or M2 phenotype is critical for the development and occurrence of inflammation and disease. An increased proportion of M1-type macrophages has been observed in inflammatory bowel disease (IBD). Macrophage-targeted hydroxychloroquine (HCQ) nanotherapeutics are highly effective treatments for autoimmune diseases. HCQ has been widely used in the tre...

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Literature Corpus work: 2cf32686-49d8-575c-9808-ecb5753ad14d
DOI: 10.21203/rs.3.rs-2134082/v1

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