Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lamina propria macrophage phenotypes in relation to Escherichia coli in Crohn's disease.

BMC gastroenterology - 3 Jul 2015

Elliott Timothy R, Rayment Neil B, Hudspith Barry N, Hands Rebecca E, Taylor Kirstin, Parkes Gareth C, Prescott Natalie J, Petrovska Liljana, Hermon-Taylor John, Brostoff Jonathan, Boussioutas Alex, Mathew Christopher G, Bustin Stephen A, Sanderson Jeremy D

Abstract excerpt

BACKGROUND: Abnormal handling of E. coli by lamina propria (LP) macrophages may contribute to Crohn's disease (CD) pathogenesis. We aimed to determine LP macrophage phenotypes in CD, ulcerative colitis (UC) and healthy controls (HC), and in CD, to compare macrophage phenotypes according to E. coli carriage. METHODS: Mucosal biopsies were taken from 35 patients with CD, 9 with UC and 18 HCs. Laser capture...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colitis, Ulcerative

Share to Crohn Disease

Share to Cytokines

Share to Escherichia coli

Share to Intestinal Mucosa

Share to Macrophages

Source

Open in PubMed Open full text

Identifiers

PMID: 26137941
DOI: 10.1186/s12876-015-0305-3
PMCID: PMC4490755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lamina propria macrophage phenotypes in relation to Escherichia coli in Crohn's disease.PMID 26137941Read ↗

Defective macrophage handling of Escherichia coli in Crohn's disease.Semantic proximity Read ↗

The role of the macrophage in sentinel responses in intestinal immunity.Semantic proximity Read ↗

Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Semantic proximity Read ↗

Macrophage polarization in inflammatory bowel disease.Semantic proximity Read ↗

Monocyte-derived macrophages from Crohn's disease patients are impaired in the ability to control intracellular adherent-invasive Escherichia coli and exhibit disordered cytokine secretion profile.Semantic proximity Read ↗

Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel diseaseSemantic proximity Read ↗

Characterising molecular mechanisms of Crohn's disease-associated Escherichia coli that enable their survival and replication within macrophagesSemantic proximity Read ↗

Colonic macrophage polarization in homeostasis, inflammation, and cancer.Semantic proximity Read ↗

Microbiota driven macrophage mediators in pathogenesis and treatment of gut leakage: current strategies and future perspectivesSemantic proximity Read ↗

Intestinal macrophages in pathogenesis and treatment of gut leakage: current strategies and future perspectivesSemantic proximity Read ↗

Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive <i>Escherichia coli</i> infectionSemantic proximity Read ↗

Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal MotilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.