Article

Azithromycin Augments Bacterial Uptake and Anti-inflammatory Macrophage Polarization in Cystic Fibrosis

2023-12-25

Abstract excerpt

<h4>Background: </h4> Azithromycin (AZM) is widely used in cystic fibrosis (CF) treatment following clinical trials demonstrating improved lung function and fewer pulmonary exacerbations. While the precise mechanisms remain elusive, immunomodulatory actions are thought to be involved. We previously reported impaired phagocytosis and defective anti-inflammatory M2 macrophage polarization in CF macrophages. This stu...

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Literature Corpus work: e12c2f1f-7a3b-5dd3-b55e-7dbe479326b1
DOI: 10.20944/preprints202312.1788.v1

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