Article
Monocyte-derived macrophages from Crohn's disease patients are impaired in the ability to control intracellular adherent-invasive Escherichia coli and exhibit disordered cytokine secretion profile.
Journal of Crohn's & colitis - 1 May 2015
Vazeille Emilie, Buisson Anthony, Bringer Marie-Agnès, Goutte Marion, Ouchchane Lemlih, Hugot Jean-Pierre, de Vallée Amélie, Barnich Nicolas, Bommelaer Gilles, Darfeuille-Michaud Arlette
Abstract excerpt
BACKGROUND: Ileal lesions of Crohn's disease [CD] patients are colonised by adherent-invasive Escherichia coli [AIEC] able to survive in macrophage cell lines. We analysed the ability of monocyte-derived macrophages [MDM] from CD patients to control AIEC intracellular replication and the pro-inflammatory cytokine response of the infected-MDM. METHODS: Peripheral blood MDM were obtained from 24 CD genotyped for...
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