Article

Meiotic Cas9 expression mediates genotype conversion in the male and female mouse germline

2021-03-17

Abstract excerpt

Highly efficient genotype conversion systems have potential to facilitate the study of complex genetic traits using laboratory mice and to limit loss of biodiversity and disease transmission caused by wild rodent populations. We previously showed that such a system of genotype conversion from heterozygous to homozygous after a sequence targeted CRISPR/Cas9 double strand DNA break is feasible in the female mouse ge...

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Literature Corpus work: 1d0a5cb7-779b-53d8-8384-d4738f0ff458
DOI: 10.1101/2021.03.16.435716

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