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Article

Genotype to Phenotype: CRISPR Gene Editing Reveals Genetic Compensation as a Mechanism for Phenotypic Disjunction of Morphants and Mutants.

International journal of molecular sciences - 27 Mar 2021

Salanga Cristy M, Salanga Matthew C

Abstract excerpt

Forward genetic screens have shown the consequences of deleterious mutations; however, they are best suited for model organisms with fast reproductive rates and large broods. Furthermore, investigators must faithfully identify changes in phenotype, even if subtle, to realize the full benefit of the screen. Reverse genetic approaches also probe genotype to phenotype relationships, except that the genetic targets...

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PMID: 33801686
DOI: 10.3390/ijms22073472
PMCID: PMC8036752

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