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Article

Meiotic drive in house mice: mechanisms, consequences, and insights for human biology.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Sept 2022

Arora Uma P, Dumont Beth L

Abstract excerpt

Meiotic drive occurs when one allele at a heterozygous site cheats its way into a disproportionate share of functional gametes, violating Mendel's law of equal segregation. This genetic conflict typically imposes a fitness cost to individuals, often by disrupting the process of gametogenesis. The evolutionary impact of meiotic drive is substantial, and the phenomenon has been associated with infertility and...

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Identifiers

PMID: 35829972
DOI: 10.1007/s10577-022-09697-2
PMCID: PMC9509409

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