Article

Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline

2018-07-04

Abstract excerpt

A gene drive biases the transmission of a particular allele of a gene such that it is inherited at a greater frequency than by random assortment. Recently, a highly efficient gene drive was developed in insects, which leverages the sequence-targeted DNA cleavage activity of CRISPR/Cas9 and endogenous homology directed repair mechanisms to convert heterozygous genotypes to homozygosity. If implemented in laboratory...

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Literature Corpus work: 4fdb73ec-fdf1-5311-b10f-584cf2f18b62
DOI: 10.1101/362558

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