Article

Increasing the effective gene drive homing rate by targeting the haploinsufficient spermatogenesis gene <i>KLHL10</i>

2025-12-26

Abstract excerpt

CRISPR-based gene drives represent a powerful new technology for limiting disease transmission and controlling invasive populations. These systems rely on homology-directed repair (HDR) to ‘drive’ a genetic element through a population. However, mammals tend to favor non-homologous end joining (NHEJ), which generates mutations that halt further drive propagation. Here, we describe the experimental characterization...

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Literature Corpus work: d2204162-deb2-52d2-b998-da3edf0a08d4
DOI: 10.64898/2025.12.22.695236

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