Article

Pretargeted brain PET imaging reveals amyloid-β pathology using a TCO-modified antibody and a fluorine-18 labelled tetrazine

2025-06-03

Abstract excerpt

<title>Abstract</title> <p>Antibody-based positron emission tomography (PET) imaging holds promise for visualising and quantifying disease-related proteins in the brain, yet clinical application has been limited by the poor blood-brain barrier (BBB) penetration of antibodies and the need for long-lived radionuclides. Pretargeted imaging offers a solution by separating the delivery of the antibody from the radiola...

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Literature Corpus work: 1d04ab47-a9c3-5dad-8589-6c1988bb186a
DOI: 10.21203/rs.3.rs-6784648/v1

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