Article
A Metal-Free Method for Producing MRI Contrast at Amyloid-β.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Hilt Silvia, Tang Tang, Walton Jeffrey H, Budamagunta Madhu, Maezawa Izumi, Kálai Tamás, Hideg Kálmán, Singh Vikrant, Wulff Heike, Gong Qizhi, Jin Lee-Way, Louie Angelique, Voss John C
Abstract excerpt
Alzheimer's disease (AD) is characterized by depositions of the amyloid-β (Aβ) peptide in the brain. The disease process develops over decades, with substantial neurological loss occurring before a clinical diagnosis of dementia can be rendered. It is therefore imperative to develop methods that permit early detection and monitoring of disease progression. In addition, the multifactorial pathogenesis of AD has...
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