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Pretargeted Imaging with Gallium-68 – Improving the Binding Capability by Increasing the Number of Tetrazine Motifs

2018-09-03

Abstract excerpt

Among extensive studies on click chemistry the inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans-cyclooct-2-en (TCO) has gained increasing attraction due to its exceptionally fast reaction kinetics and high selectivity for in vivo pretargeting applications including PET imaging. The facile two-step approach utilizing TCO-modified antibodies as targeting structures has not made i...

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Literature Corpus work
28ff1763-6692-56c0-a159-2652a78f44b5
DOI
10.20944/preprints201809.0048.v1
Open publication

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