Article

Radionuclide selection influences imaging outcomes in immunoPET with a brain-penetrant anti-Aβ antibody

2025-06-03

Abstract excerpt

<h4>Background</h4> Bispecific antibodies exploiting receptor-mediated transcytosis offer a promising strategy to overcome limited blood-brain barrier permeability in Alzheimer’s disease (AD) therapy and imaging. Lecanemab-Fab8D3 (Lec-Fab8D3), a bispecific anti-amyloid beta (Aβ) antibody engineered for enhanced brain delivery, holds potential as a companion immunoPET imaging diagnostic with the novel lecanemab im...

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Literature Corpus work: 10ae505b-ebd8-538a-b653-6b6e1f804f63
DOI: 10.1101/2025.05.31.657140

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