Article

ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma

2020-07-29

Abstract excerpt

Phagocytic immunotherapies such as CD47 blockade have emerged as promising strategies for glioblastoma (GB) therapy, but the blood brain/tumor barriers (BBB/BTB) pose a persistent challenge for mCD47 delivery that can be overcome by focused ultrasound (FUS)-mediated BBB/BTB disruption. We here leverage immuno-PET imaging to determine how timing of [ 89 Zr]-mCD47 injection relative to FUS impacts antibody penetran...

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Literature Corpus work: f2d66509-4a10-58d6-a7d0-45026c1a3135
DOI: 10.1101/2020.07.27.223206

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