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Brain-Penetrating Peptide and Antibody Radioligands for Proof-of-Concept PET Imaging of Fibrin in Alzheimer’s Disease

2025-06-05

Abstract excerpt

<h4>Background</h4> Alzheimer’s disease (AD) is increasingly recognized as a multifactorial disorder with vascular contributions, including a pro-coagulant state marked by fibrin deposition in the brain. Fibrin accumulation may exacerbate cerebral hypoperfusion, leading to neurodegeneration. Identifying patients with this pathology could enable targeted anticoagulant therapy. However, current imaging tools lack t...

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Literature Corpus work
4d88a0bb-97f9-5b91-af66-0d101246632f
DOI
10.1101/2025.06.02.657356
Open publication

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